Methods Development for Early Phase CAM Trials [NCCAM]

Mikel Aickin, PhD
Early-phase CAM research is at a disadvantage for several reasons having to do with the inappropriate application of Phase III methods in Phase I trials.  This project will conduct statistical and literature-based research on four of these areas of methodology (1) design-adaptive allocation in place of randomization, (2) paired availability to deal with missing data, (3) the benefits of replacing null hypothesis testing with separation tests, and (4) development of a clinic-based version of RCTs, using modern causal analysis.